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This study aimed to assess the status of cell mediated immunity for pulmonary tuberculosis patients through evaluation levels of Interleukins (IFN-γ ,IL-10, IL-12) and estimation vitamin D3 . Whole blood samples collected from 50 pulmonary tuberculosis patients who are admitted to consultant clinic for respiratory diseases in Hilla – Babylon province during the period from February 2016 to February 2017. Out of the pTB patients, there were 27 males and 23 females, the patients age range was between 12-80 years. Cytokines levels and vitamin D3 estimated by using ELISA technique. The mean of serum concentration of IL-10 and IL-12 revealed that there is a significantly increased (p˂ 0.05) in pulmonary tuberculosis patients as compared to controls (4.024 and 1.049)pg/ml (51.563 and 13.514) pg/ml ,respectively. While, the mean of serum concentration of IFN-γ showed no significant increasing (p˃0.05) in pulmonary tuberculosis patients compared to controls (36.505 and 25.019)pg/ml. The mean of serum concentration of VD3 showed a significant decreasing (p˂ 0.05) in pulmonary tuberculosis patients as compared to controls (18.186 and 29.321) ng/ml.
The results provide a good correlation between the levels of IL-10 , IL-12, IFN-γ and Vitamin D3 with the cellular immunity against pulmonary tuberculosis.