Estimation of some Immunological Factors in Pulmonary Tuberculosis Patients

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Ashwaq M. S. Al-Jubouri
Mohammed A. K. Al-Saadi
Hadi M. A. Al-Mosawi

Abstract

This study aimed to assess the status of cell mediated immunity for pulmonary tuberculosis patients through evaluation levels of Interleukins (IFN-γ ,IL-10, IL-12) and estimation vitamin D3 . Whole blood samples collected from 50 pulmonary tuberculosis patients who are admitted to consultant clinic for respiratory diseases in Hilla – Babylon province during the period from February 2016 to February 2017. Out of the pTB patients, there were 27 males and 23 females, the patients age range was between 12-80 years. Cytokines levels and vitamin D3 estimated by using ELISA technique. The mean of serum concentration of IL-10  and IL-12 revealed that there is a significantly increased (p˂ 0.05) in pulmonary tuberculosis patients as compared to controls (4.024 and 1.049)pg/ml (51.563 and 13.514) pg/ml ,respectively. While, the mean of serum concentration of IFN-γ showed no significant increasing (p˃0.05) in pulmonary tuberculosis patients compared to controls (36.505 and 25.019)pg/ml.  The mean of serum concentration of VD3 showed a significant decreasing (p˂ 0.05) in pulmonary tuberculosis patients as compared to controls (18.186 and 29.321) ng/ml.


Conclusions:


The results provide a good correlation between the levels of  IL-10 , IL-12, IFN-γ and Vitamin D3 with the cellular immunity against pulmonary tuberculosis.

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How to Cite
[1]
A. M. S. Al-Jubouri, M. A. K. Al-Saadi, and H. M. A. Al-Mosawi, “Estimation of some Immunological Factors in Pulmonary Tuberculosis Patients”, JUBPAS, vol. 26, no. 9, pp. 39-49, Dec. 2018.
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