Effects of Aluminum Chloride on the some ‎Blood Parameters and Histological Spleen in ‎White Male Rats

Abstract

Aluminum exists in numerous produced foods, medicines and likewise added to drinking water for refining purpose. Its existence has so heavily contaminated with the surroundings that exposed to, it is almost inescapable. This survey was aimed at evaluating the possible effects that Aluminum chloride could exposure have in the blood parameters and histopathology of spleen twenty four rats were used and  divided into four groups; “first group  was the control injected with normal saline, group II injected into subcutaneous with (240) ppm from Aluminum chloride (AlCl₃),  group III injected with (320) ppm from (AlCl₃), group IV injected with (400 ) ppm from (AlCl₃) for 45 days. This study  showed a significant decrease (P<0.05) in red blood cell count, hemoglobin concentration, packed cell volume, mean corpuscular volume and mean corpuscular hemoglobin when compared to control group, while there was a significant increase (P<0.05) in total leucocyte count (TLC) and Differential leucocytes count (DLC) especially in lymphocyte. The results showed a significant elevated (P<0.05) in ESR value. Changes increased with increase in concentration of Aluminum chloride injected. Observation of blood parameters allows the most rapid detection of changes in wistar rats after the exposure of poisonous(AlCl₃)”