Correlation between Packed Cell Volume and ‎Concentration of Clotting Factors FI, FVII, and ‎FVIII in Smokers Polycythemic males in Babylon ‎Province

Authors

  • Dakhel Ghani Omran University of Babylon, College of Science for women, College of Science for women, ‎Department of biology
  • Rasha hamza Abd Al-Hussien University of Babylon, College of Science for women, College of Science for women, ‎Department of biology

Keywords:

Polycythemia, clotting factors, ‎, smoking‎

Abstract

Smoking represents a worldwide problem and affects various body functions. The present study was conducted to evaluate the available concentration of some clotting factors in smokers polycythemic male patients. A total number of subjects was 120, 80 smokers males were affected with polycythemia and the remainders 40 males were healthy and served as a control group. The polycythemic patients were subdivided into two groups according to their ages (first group ranged between 30-40 years old and the second group ranged between 41-50 years old). PCV, clotting factor (FI, FVII and FVIII) were detected. The results of present study indicated that the levels of prothrombin time (PT) and activated partial thromboplastine time (APTT) were significantly increased (p˂ 0.05) in both groups of polycythemia in comparison with control group. Regarding concentration of fibrinogen factor (FI) and serum prothrombin conversion accelerator factor (FVII) were elevated (P˂ 0.05) in both groups and pointed  out a positive correlation (r = 0.437, r = 0.378, respectively) with packed cell volume (PCV) when compared with those of control group. On the other hand, concentration of antihemophilic factor (FVIII) recorded a significant fall (p˂ 0.05) in both tested groups and indicated a low correlation (r = 0.292). The possible explanation to the changes mentioned above is based on the fact that confirm smoking is a dangerous material containing different toxic substances that affect the vital organs of the body and induce abnormalities of hemostatic mechanism

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Published

2017-11-30

How to Cite

[1]
D. G. Omran and R. hamza Abd Al-Hussien, “Correlation between Packed Cell Volume and ‎Concentration of Clotting Factors FI, FVII, and ‎FVIII in Smokers Polycythemic males in Babylon ‎Province”, JUBPAS, vol. 25, no. 5, pp. 1682-1974, Nov. 2017.

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